助理教授，博士生导师
学科：创新药研发与金属蛋白（酶）的化学生物学研究
联系信息
邮箱： runmingwang@sz.tsinghua.edu.cn
地址： 深圳市南山区西丽深圳大学城清华校区D楼303C室
教育经历
2014年01月-2018年02月，香港大学，生物无机化学专业，博士（导师：孙红哲教授，高一村副教授）
2012年09月-2013年12月，武汉工程大学，分析化学，其他（导师：陈嵘教授）
2008年09月-2012年07月，武汉工程大学，食品科学与工程专业，学士
工作经历
2022年02月-至今，清华大学深圳国际研究生院，助理教授
2018年10月-2021年10月，香港大学，博士后
2018年4月-2018年9月，香港大学，研究助理
学术兼职
《Infectious Diseases Reviews》杂志编辑委员会委员(Editorial Board Member)
《Frontiers in Environmental Chemistry》杂志客座编辑（Guest Editor）
研究领域
王润铭博士于2022年2月加入清华大学深圳国际研究生院生物医药与健康工程研究院任助理教授，从事生物无机化学、材料化学和微生物学的交叉科学领域的研究，致力于挖掘和拓展无机药物及相关小分子在生物医药方向的应用和发展。
任何生命都离不开金属和金属蛋白。王润铭博士的研究兴趣落脚于金属蛋白（酶）的化学生物学以及生物工程学。通过使用创新药物和相关的化学、生物学工具，对病原细菌、病毒和真核细胞中关键金属蛋白（酶）的结构和功能进行调控，王博士旨在攻克抗菌素耐药性、COVID-19、恶性肿瘤以及衰老等重大问题。
郑重邀请各位有志的硕士研究生、博士研究生及博士后加入王润铭博士的研究团队！
主要项目
1. Discovery of metallo-agents as antimicrobial resistance breakers, 2019/20 PROCORE-France/Hong Kong Joint Research Scheme （F-HKU704/19），香港研究资助局基金，2020/02-2022/01，已结题，共同主持（Co-PI）
2. Development of metallo-antiviral agents for combating COVID-19，香港大学种子基金，2021/04-2023/03，在研，共同主持（Co-I）
3. Development of novel inhibitors for combatting SARS-CoV-2 infection（ITS/278/20），香港创新及科技基金，2021/04-2022/06，在研，参与（核心成员）
4. Discovery and preclinical evaluation of bismuth (III) complexes with porphyrins and thiolates as new antagonists against side effect of cisplatin（ITS/124/17），2018/01-2019/05，已结题，参与（核心成员）
5. Combination approach to combat metallo-β-lactamase positive superbugs（R7070-18），香港研究资助局基金，2019/09-2024/08，在研，参与
Research Interests
# Co-first author, * Correspondence author
Qi Z#, Wang R#, Wang M, Liu C, Koohi-Moghadam M, Wang H, Ho P-L, Li H, Sun H*,”Re-sensitization of mcr carrying multidrug resistant bacteria to 3 colistin by silver, Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2119417119.
Wang R#, Chan J. F-W#, Wang S#, Li H, Zhao J, Ip K-Y, Zuo Z, Yuen K-K, Yuan S*, Sun H*, Orally administrated bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy. Chem. Sci., 2022, 13, 2238-2248 [Back cover]
Yuan S#, Wang R#, Chan FW#, Zhang J, Cheng T, Chik KH, Ye Z-W, Wang S, Jin L, Li H, Jin DY, Yuen KY*, Sun H*, Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters, Nat. Microbiol, 2020, 5, 1439–1448. [Local Top Ten innovation and technology news in 2020]]
Sun H#*, Zhang Q#, Wang R#*, Wang H, Wong YT, Wang M, Hao Q, Yan A, Kao YT, Ho PL, Li H, Resensitizing superbugs carrying both blaMBL and mcr genes to antibiotics by auranofin, Nat. Commum., 2020, 11, 5263.
Wang R, Wang S, Chan S, Wang Y, Zhang Y, Zuo Z, Chan CF, Li H, Sun H*, Bismuth porphyrin antagonizes cisplatin-induced nephrotoxicity via unexpected metallothionein-independent mechanisms, iScience, 2020, 23, 101054.
Wang R#, Lai TP#, Gao P#, Zhang H#, Ho PL, Woo PC, Ma G, Kao RYT, Li H, Sun H*. Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nat. Commum., 2018, 9, 439.[Highly cited paper]
WangR#, Cheng G#, Dai Z, Ding J, Liu Y, Chen R*, Ionic liquid-employed synthesis of Bi2E3 (E=S, Se, and Te) hierarchitectures: the case of Bi2S3 with superior visible-light-driven Cr(VI) photoreduction capacity, Chem. Engineer. J., 2017, 327, 371-386.
Chan S#, Wang R#, Man K, Nicholls J, Li H, Sun H*, Chan GC*.Transl Oncol. 2016, 12, 788-799
Yuan S, Yin X, Meng X, Chan F-W, Ye Z-W, Riva L, Pache L, Chan C-Y, Lai P-M, Chan C-S, Poon K-M, Lee C-Y, Matsunaga N, Pu Y, Yuen C-K, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau C-Y, Sit KY, Au W-K, Wang R, Zhang Y-Y, Tang Y, Clausen T, Pihl J, Oh J, Sze K-H, Zhang J, Chu H, Kok K-H, Wang D, Cai X-H, D. Esko J, Hung F-N, Li R, Chen H, Sun H, Jin D-Y, Sun R, K. Chanda S, Yuen K-Y. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2, Nature, 2021, 593, 418–423.
Li H, Wang R, Sun H. Systems approaches for unveiling the mechanism of action of bismuth drugs: new medicinal applications beyond helicobacter pylori infection accounts of chemical research, Acc. Chem. Res. 2019 52, 216-227
Other relevant publications can be accessed via the following ways：
Google scholar link: https://scholar.google.com/citations?user=DWNINfAAAAAJ&hl=en&oi=ao
ORCID link: https://orcid.org/0000-0001-8525-5659
Research gate link：https://www.researchgate.net/profile/Runming-Wang
Projects
Wang R, Li H, Ip K-Y, Sun H. Chapter Six - Bismuth drugs as antimicrobial agents, Academic Press; 1st edition, 2020
Wang R,Li H,Sun H. Bismuth: Environmental Pollution and Health Effects, Elsevier, 2019
Research Output
1. Sun H, Kao YT, Wang R, L TP, Zhang H, Li H，Bismuth(III) compounds and methods thereof，专利号：US10201518B2，美国专利及商标局，已授权
2. Sun H, Chan CF, Wang R, Chan S，Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy，专利号：US20170014448A1，US20170014448A1，美国专利及商标局，已公开
代表性论文
# Co-first author, * Correspondence author
Qi Z#, Wang R#, Wang M, Liu C, Koohi-Moghadam M, Wang H, Ho P-L, Li H, Sun H*,”Re-sensitization of mcr carrying multidrug resistant bacteria to 3 colistin by silver, Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2119417119.
Wang R#, Chan J. F-W#, Wang S#, Li H, Zhao J, Ip K-Y, Zuo Z, Yuen K-K, Yuan S*, Sun H*, Orally administrated bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy. Chem. Sci., 2022, 13, 2238-2248 [Back cover]
Yuan S#, Wang R#, Chan FW#, Zhang J, Cheng T, Chik KH, Ye Z-W, Wang S, Jin L, Li H, Jin DY, Yuen KY*, Sun H*, Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters, Nat. Microbiol, 2020, 5, 1439–1448. [Local Top Ten innovation and technology news in 2020]]
Sun H#*, Zhang Q#, Wang R#*, Wang H, Wong YT, Wang M, Hao Q, Yan A, Kao YT, Ho PL, Li H, Resensitizing superbugs carrying both blaMBL and mcr genes to antibiotics by auranofin, Nat. Commum., 2020, 11, 5263.
Wang R, Wang S, Chan S, Wang Y, Zhang Y, Zuo Z, Chan CF, Li H, Sun H*, Bismuth porphyrin antagonizes cisplatin-induced nephrotoxicity via unexpected metallothionein-independent mechanisms, iScience, 2020, 23, 101054.
Wang R#, Lai TP#, Gao P#, Zhang H#, Ho PL, Woo PC, Ma G, Kao RYT, Li H, Sun H*. Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nat. Commum., 2018, 9, 439.[Highly cited paper]
WangR#, Cheng G#, Dai Z, Ding J, Liu Y, Chen R*, Ionic liquid-employed synthesis of Bi2E3 (E=S, Se, and Te) hierarchitectures: the case of Bi2S3 with superior visible-light-driven Cr(VI) photoreduction capacity, Chem. Engineer. J., 2017, 327, 371-386.
Chan S#, Wang R#, Man K, Nicholls J, Li H, Sun H*, Chan GC*.Transl Oncol. 2016, 12, 788-799
Yuan S, Yin X, Meng X, Chan F-W, Ye Z-W, Riva L, Pache L, Chan C-Y, Lai P-M, Chan C-S, Poon K-M, Lee C-Y, Matsunaga N, Pu Y, Yuen C-K, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau C-Y, Sit KY, Au W-K, Wang R, Zhang Y-Y, Tang Y, Clausen T, Pihl J, Oh J, Sze K-H, Zhang J, Chu H, Kok K-H, Wang D, Cai X-H, D. Esko J, Hung F-N, Li R, Chen H, Sun H, Jin D-Y, Sun R, K. Chanda S, Yuen K-Y. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2, Nature, 2021, 593, 418–423.
Li H, Wang R, Sun H. Systems approaches for unveiling the mechanism of action of bismuth drugs: new medicinal applications beyond helicobacter pylori infection accounts of chemical research, Acc. Chem. Res. 2019 52, 216-227
Other relevant publications can be accessed via the following ways：
Google scholar link: https://scholar.google.com/citations?user=DWNINfAAAAAJ&hl=en&oi=ao
ORCID link: https://orcid.org/0000-0001-8525-5659
Research gate link：https://www.researchgate.net/profile/Runming-Wang
代表性著作
Wang R, Li H, Ip K-Y, Sun H. Chapter Six - Bismuth drugs as antimicrobial agents, Academic Press; 1st edition, 2020
Wang R,Li H,Sun H. Bismuth: Environmental Pollution and Health Effects, Elsevier, 201
主要专利成果
1. Sun H, Kao YT, Wang R, L TP, Zhang H, Li H，Bismuth(III) compounds and methods thereof，专利号：US10201518B2，美国专利及商标局，已授权
2. Sun H, Chan CF, Wang R, Chan S，Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy，专利号：US20170014448A1，US20170014448A1，美国专利及商标局，已公开
Books
1.Faculty Knowledge Exchange (KE) Award (Team)，The University of Hong Kong, Hong Kong, 2021
2.HKU-Pasteur Research Pole Fellowship, Hong Kong，2021 (declined)
3.Best Oral Presentation Award of 9th Asian Biological Inorganic Chemistry Conference, Singapore, 2018
4.Royal Society of Chemistry Books Awards of 8th Asian Biological, Auckland, New Zealand 2016
5.Outstanding Teaching Assistant, The University of Hong Kong, Hong Kong 2015.
6.湖北省第九届”挑战杯·青春在沃”大学生课外学术科技作品竞赛二等奖 (第一发明人), 武汉，2013
7.湖北省优秀学士论文，武汉，2012
荣誉奖项
1.Faculty Knowledge Exchange (KE) Award (Team)，The University of Hong Kong, Hong Kong, 2021
2.HKU-Pasteur Research Pole Fellowship, Hong Kong，2021 (declined)
3.Best Oral Presentation Award of 9th Asian Biological Inorganic Chemistry Conference, Singapore, 2018
4.Royal Society of Chemistry Books Awards of 8th Asian Biological, Auckland, New Zealand 2016
5.Outstanding Teaching Assistant, The University of Hong Kong, Hong Kong 2015.
6.湖北省第九届”挑战杯·青春在沃”大学生课外学术科技作品竞赛二等奖 (第一发明人), 武汉，2013
7.湖北省优秀学士论文，武汉，2012
