助理教授，博士生导师
学科：化学工程与技术
联系信息
电话： 0755-2640 1402
邮箱： zhang.cy@sz.tsinghua.edu.cn
地址： 清华大学深圳国际研究院信息楼1208
概况
张灿阳，清华大学深圳国际研究生院助理教授、博士生导师、特别研究员。2014年博士毕业于华南理工大学化学工程专业（导师：章莉娟教授、钱宇教授），期间于德国慕尼黑大学联合培养（导师：Ernst Wagner院士），先后于华盛顿州立大学（合作导师：Zhenjia Wang教授）、麻省理工学院（新加坡科研中心，合作导师：Paula Hammond院士）从事博士后研究。主要从事功能生物医用材料设计与开发，靶向递送与控缓释技术研发，免疫调控，生物医用器件研发，面向肿瘤诊疗、抗菌抗感染、炎症免疫调控等应用的制剂工程研究等。迄今已发表学术论文40余篇，其中第一/通讯作者文章30余篇，包括Sci. Adv.、Adv. Mater.、Biomaterials、Bioact. Mater.、Chem. Eng. J.、J. Control. Release、Biomaterials、AIChE J.等国际高水平期刊，H-因子24。
教育经历
2009年09月-2014年12月，华南理工大学，化学工程专业，博士
2012年10月-2013年10月，慕尼黑大学，药学科技专业，联合培养
2005年09月-2009年06月，西南民族大学，化学工程与工艺专业，学士
工作经历
2021年5月-至今，清华大学深圳国际研究生院，助理教授
2019年06月-2020年12月，麻省理工学院-新加坡科研中心，博士后
2016年08月-2019年06月，华盛顿州立大学，博士后
2015年03月-2016年08月，国家纳米科学中心，助理研究员
学术兼职
Pharmaceutics、International Journal of Polymer Science杂志客座编辑；Journal of Future Foods编委
教学课程
生物物理化学、实验生物学
研究领域
研究方向重点是面向生物医药与生命健康领域重大需求与问题，设计和开发多功能工程化生物材料载体和递送（剂型）策略，用于疾病诊断与治疗，如癌症、感染、自身免疫性疾病。主要有四个研究方向:
1)刺激-响应型（聚β-氨基酯）材料库的设计（计算机辅助和模拟）与建立；
2)细胞介导的免疫调控靶向系统的开发；
3)基于产品工程与制剂工程的生物医药与健康工程研究；
4)微针相关技术与产品开发。
课题组招收博士后、科研助理、博士研究生、以及硕士研究生，欢迎具有化学工程与技术、化学、材料科学与技术、生物学、微生物学、药学、食品工程、医学、生物医学工程等背景的同学加盟。
Website: https://zhanglab.sigs.tsinghua.edu.cn/
主要项目
国家自然科学基金、美国NIH项目、新加坡A*Star项目。
成果：已发表37篇学术论文，第一/通讯作者文章26篇，包括Science Advances、Advanced Materials、Biomaterials、Journal of Controlled Release等期刊，申请授权多项发明专利。
代表性论文
[1]Yan Wang #, Juan Li#, Jinping Shi, Junyu Liu, Can Yang Zhang*, Graphene-based nanomaterials for cancer therapy and anti-infections, Bioactive Materials. 2022, 14, 335-349.
[2]Wen Xuan Li, Xiao Peng Zhang, Bo Zhi Chen, Wen Min Fei, Yong Cui*, Can Yang Zhang*, Xin Dong Guo*, An update on microneedle-based systems for diabetes, Drug Delivery and Translational Research. 2022, 1-12.
[3]Yun Hao Feng, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang*, Xin Dong Guo*, Mechanism studies on the cellular internalization of nanoparticles using computer simulations: A review, AIChE Journal, 2022, e17507.
[4]Jinping Shi#, Juan Li#, Yan Wang, Xiaobin Li, Can Yang Zhang*, TiO2-based Nanosystem for Cancer Therapy and Antimicrobial Treatment: A Review. Chemical Engineering Journal. 2021, 431, 133714.
[5]黄龙;曾文;徐冰;张灿阳;马少华;张翀;王怡*;邢新会*, 口服多糖靶向药物递送体系在结肠疾病治疗中的应用研究进展, 药学学报, 2021, 1073.
[6]Yan Wang,Yuanjun Ma,Jinping Shi,Xianyu Yan,Jun Luo, Huilong Zhu, Kunpeng Jia*, Juan Li*,Can Yang Zhang*, Surface modification of monolayer MoS2 by baking for biomedical application, Frontiers in Chemistry, 2020, 8:741.
[7]Shuguang Zhang,Peiyao Zhu,Jiayuan He,Siyuan Dong,Peiwen Li,Can Yang Zhang*, Teng Ma*,TME-Responsive Polyprodrug Micelles for Multistage Delivery of Doxorubicin with Improved Cancer Therapeutic Efficacy in Rodents, Advanced Healthcare Materials, 2020, 9(18), 2000387.
[8]Jinping Shi, Juan Li*, Yan Wang, Jingjing Cheng, Can Yang Zhang*, Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment, Journal of Materials Chemistry B, 2020, 8, 5793-5807.
[9]Can Yang Zhang, Xinyue Dong, Jin Gao, Wenjing Lin, Ze Liu, Zhenjia Wang*, Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke, Science Advances, 2019, 5(11), eaax7964.
[10]Can Yang Zhang, Wenjing Lin, Jin Gao, Xutong Shi, Maryam Davaritouchaee, Amy Nielsen, Rock Mancini, Zhenjia Wang*. pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury, ACS Applied Materials & Interfaces, 2019, 11(18), 16380-16390.
[11]Mengzhen Xu#, Can Yang Zhang#, Junguang Wu, Huige Zhou, Ru Bai, Ziyi Shen, Ying Liu*, and Jing Liu*, PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release, ACS Applied Materials & Interfaces, 2019,11(6), 5701-5713.
[12]Xutong Shi, Can Yang Zhang*, Jin Gao, Zhenjia Wang*, Recent Advances in Photodynamic Therapy for Cancer and Infectious Diseases, Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2019, e1560.
[13]Yongle Luo, Xujun Yin, Xi Yin, Anqi Chen, Lili Zhao, Gang Zhang, Wenbo Liao, Xiangxuan Huang*, Juan Li and Can Yang Zhang*, Dual pH/Redox-Responsive Mixed Polymeric Micelles for Anticancer Drug Delivery and Controlled Release, Pharmaceutics, 2019, 11(4), 176.
[14]Wen Yao Hu, Zhi Min Wu*, Qian Qian Yang, Yue Jin Liu, Juan Li, Can Yang Zhang*, Smart pH-responsive cationic polymeric micelles for programmed oral delivery of insulin, Colloids and Surfaces B: Biointerfaces, 2019, 183:110443-11-453.
[15]Zhimin Wu*, Manzhen Duan, Di Xiong, Can Yang Zhang*, Mesoscale Simulations of pH-Responsive Polymeric Micelles for Oral Drug Delivery, Pharmaceutics, 2019, 11, 620.
[16]Can Yang Zhang, Jin Gao, Zhenjia Wang*. Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management. Advanced Materials, 2018, 30(43), 1803618.
[17]Juan Li, Yuan Jun Ma, Yan Wang, Bo Zhi Chen, Xin Dong Guo*, Can Yang Zhang*. Dual redox/pH-responsive hybrid polymer-lipid composites: Synthesis, preparation, characterization and application in drug delivery with enhanced therapeutic efficacy. Chemical Engineering Journal, 2018, 341, 450-461.
[18]Qi Lei Wang, Jia Wei Ren, Bo Zhi Chen, Xuan Jin, Can Yang Zhang*, Xin Dong Guo*. Effect of humidity on mechanical properties of dissolving microneedles for transdermal drug delivery. Journal of Industrial and Engineering Chemistry, 2018, 59, 251-258.
[19]Xiangxuan Huang, Wenbo Liao, Zhihao Xie, Deshi Chen, Can Yang Zhang*. A pH-responsive prodrug delivery system self-assembled from acid-labile doxorubicin-conjugated amphiphilic pH-sensitive block copolymers. Materials Science & Engineering C-Materials for Biological Applications. 2018, 90, 27-37.
[20]Can Yang Zhang, Shiyuan Peng, Bin Zhao, Wenji Luo, Lijuan Zhang*. Polymeric micelles self-assembled from amphiphilic polymers with twin disulfides used as siRNA carriers to enhance the transfection. Materials Science & Engineering C-Materials for Biological Applications, 2017, 546-552.
[21]Can Yang Zhang, Quan Chen, Wen Sheng Wu, Xin Dong Guo, Cheng Zhi Cai, Li Juan Zhang*. Synthesis and evaluation of cholesterol-grafted PEGylated peptides with pH-triggered property as novel drug carriers for cancer chemotherapy. Colloids and Surfaces B: Biointerfaces, 2016, 11 (142): 55-64.
[22]Can Yang Zhang, Petra Kos, Katharina Müller, Waldemar Schrimpf, Christina Troiber, Ulrich Lächelt, Claudia Scholz, Don C. Lamb, Ernst Wagner*. Native chemical ligation for conversion of sequence-defined oligomers into targeted pDNA and siRNA carriers. Journal of Controlled Release, 2014, 180, 42-50.
[23]Can Yang Zhang, You Qiang Yang, Tu Xiong Huang, Bin Zhao, Xin Dong Guo, Ju Fang Wang, Li Juan Zhang*. Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery. Biomaterials, 2012, 33, 6273-6283.
Other relevant publications can be accessed via the following ways：
Google scholar link: https://scholar.google.com/citations?hl=zh-CN&user=xE1GL4gAAAAJ
ORCID link: https://orcid.org/0000-0002-6975-5781
荣誉奖项
深圳市海外高层次人才，2021
山东省泰山学者，2020
