讲师，硕士生导师
学科：化学生物学
联系信息
电话： 13510944668
邮箱： lin.jinshun@sz.tsinghua.edu.cn
地址： 清华大学深圳研究生院J楼402B
教育经历
2008年09月-2013年01月，清华大学，博士
2005年09月-2008年07月，沈阳药科大学，硕士
2001年09月-2005年07月，齐齐哈尔大学，学士
工作经历
2019年08月-至今，清华大学深圳国际研究生院，讲师
2018年03月-2019年08月，清华大学深圳研究生院，讲师
2015年07月-2018年02月，中国科学院大连化学物理研究所与南方科技大学联培，博士后
2013年03月-2015年08月，南方科技大学，Research Fellow（助理研究员）
教学课程
《合成有机化学》、《有机波谱学》和《药物化学专题实验》
研究领域
主要研究方向：(1) 基于人工智能（AI）技术的多靶点抗肿瘤小分子化合物的设计、合成及其活性研究；(2) 手性药物导向的过渡金属/小分子协同催化的不对称合成。目前已经在化学类国际一流刊物(Angew. Chem. Int. Ed.2019, 58, 7092. J. Am. Chem. Soc.2019, 141, 1074. Chem2017. 3, 979. Nat. Commun 2017,8, 14841.J. Am. Chem. Soc.2016, 138, 9357. Angew. Chem. Int. Ed. 2015, 54, 7847)上发表等文章33篇，其中多篇文章被Chem, Synfacts,Chin. J. Org. Chem.等杂志亮点评述，3篇论文入选高被引论文（top 1%)，总被引用1300多次，H-INDEX为18。
(https://publons.com/researcher/4351953/jin-shun-lin/publications/)
主持国家自然科学基金青年基金1项(21602098)和省部共建肿瘤化学基因组学国家重点实验室自主研究课题项目1项(080400015)；参与国家自然科学基金优秀青年科学基金项目、国家自然科学基金面上项目，深圳市科创委基金项目等多项基金项目。
代表性论文
1.Jin-Shun Lin #, Tao-Tao Li #, Guan-Yuan Jiao #, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and XinYuan Liu*. “Chiral Brønsted Acid-Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes. Angew. Chem. Int. Ed.2019, 58, 7092. (#Co-first author)
Highlighted in Synfacts2019, 15, 662.
2.Jin-Shun Lin #, Tao-Tao Li #, Ji-Ren Liu #, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Yu-Long Guo, Xin Hong* and Xin-Yuan Liu*.”Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes’’. J. Am. Chem. Soc. 2019, 141, 1074. (#Co-first author)
Highlighted in Synfacts2019, 15, 0255.
3.Fu-Li Wang #, Xiao-Yang Dong #, Jin-Shun Lin#,Yang Zeng, Guang-Yuan Jiao, Qiang-Shuai Gu, Xiang-Qi Guo, Can-Liang Ma, Xin-Yuan Liu*.”Catalytic Asymmetric Radical Diamination of Alkenes. Chem 2017. 3, 979. (#Co-first author)
Highlighted in Chem2017, 3, 919.
4.Jin-Shun Lin #, Fu-Li Wang #, Xiao-Yang Dong #, Wei-Wei He, Yue Yuan, Su Chen, Xin-Yuan Liu*. “Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes with Fluoroalkylsulfonyl Chlorides: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines”. Nat. Commun.2017,8, 14841. (#Co-first author).
5.Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu*. “A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes”. J. Am. Chem. Soc. 2016, 138, 9357.
Highlighted in Synfacts, 2016, 12, 1020.Highlighted in Chin. J. Org. Chem.2016, 36, 2247.
6.Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu*. “Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter”. Angew. Chem. Int. Ed.2015, 54, 7847.
Highlighted in Chin. J. Org. Chem., 2015, 35, 1802.
7.Lijuan Liu#, Zhichao Shi#, Xun Zhang, Feng Zhan, Jin-Shun Lin,* and Yuyang Jiang*. “Synthesis of α-Amino Tertiary Alkylperoxides by Lewis AcidCatalyzed Peroxidation of 1,3,5-Triazines”. Chem Asian J. 2021,16, 3487. (#Co-first author)
8.Zhichao Shi#, Tingting Fan#, Xun Zhang Feng Zhan, Zhe Wang,Lei Zhao, Jin-Shun Lin* and Yuyang Jiang*. “Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity”. Adv. Synth. Catal. 2021,363, 2619. (#Co-first author)
9.Zhe Wang #, Jiang-Tao Cheng #, Zhichao Shi, Na Wang, Feng Zhan, Sheng-Peng Jiang, Jin-Shun Lin,* Yuyang Jiang,* and Xin-Yuan Liu.* “Catalytic Asymmetric Intermolecular RadicalAminotrifluoromethylation of Alkenes with Hydrazines by Cu(I)/CPA Cooperative Catalysis”.ChemCatChem2021, 13, 185. (#Co-first author).
10.Qinglu Zuo, Zhichao Shi, Feng Zhan, Zhe Wang, Jin-Shun Lin,*Yuyang Jiang,*”TfOH-catalyzed Formal [3+2] Cycloaddition of N-tosylaziridine Dicarboxylates and Nitriles: Synthesis of Tetrafunctionalized 2-Imidazolines”.Tetrahedron Lett.2020, 61, 151576.
11.Yueying Zhang, Dan Gao,* Shangfu Li, Weili Wei, Jinshun Lin and Yuyang Jiang “1,5-Diaminonaphthalene functionalized carbon nanodots as a novel matrix for the analysis of small molecules by matrix-assisted laser desorption/ionization mass spectrometry”.Anal. Methods 2019, 11, 1131.
12.Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles”. Chem. Eur. J.2014, 20, 1332.
13.Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu*. “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles”. J. Org. Chem. 2014, 79, 7084.
14.Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu*. “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene”.Angew. Chem. Int. Ed.2014, 53, 11890.
Highlighted in Synfacts, 2014, 10, 1281.
15.Zigao Yuan, Shaopeng Chen, Chunmei Gao, Qiuzi Dai, Cunlong Zhang, Qinsheng Sun, Jin-Shun Lin, Chun Guo, Yuzong Chen, Yuyang Jiang.* “Development of a versatile DNMT and HDAC inhibitor C02S modulating multiple cancer hallmarks for breast cancer therapy”. Bioorg Chem.2019, 87, 200.
荣誉奖项
1.Shenzhen High-level Professional Reserve Talent, Shenzhen, 2020.
2.The winner of SUSTech Presidential Postdoctoral Fellowship (Top 10%), SUSTech, China. 2017.
